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Abstract #2023

Metabolic Imaging with 3D Echo Planar Spectroscopic Imaging at 7 Tesla

Sankar Seramani1, Yevgen Marchenko2, Sanjay K. Verma2, Bhanu Prakash K.N. 2, Navin Michael2, Suresh Anand Sadananthan2, Andrew A. Maudsley3, Sendhil S. Velan2, 4

1Laborartory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore , Singapore; 2Laborartory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore; 3Miller School of Medicine, University of Miami, Miami, FL, United States; 4Clinical Imaging Research Centre, Agency for Science, Technology and Research, Singapore , Singapore

3D Echo Planar Spectroscopic Imaging (EPSI) is one of the promising fast spectroscopic imaging techniques to map the regional metabolite concentrations within clinically feasible time. Whole brain distributions of NAA, tCr, and tCho and its ratios can be measured using the 3D EPSI. We have implemented a 3D EPSI sequence on a 7T MRI/MRS scanner and demonstrated it in a phantom with a voxel resolution of 2mm3 and on a rat brain. Regional metabolite distributions of NAA, Creatine & Choline and its ratios were computed using MIDAS Software. The feasibiility of mapping whole brain NAA, Cr, Cho concentrations is demonstrated from the rat brain.

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