Meeting Banner
Abstract #2003

in vivo Localized Correlated Spectroscopy Using Spectral Spatial Coherence Transfers

Galen D. Reed1, Trey Jalbert1, Gerd Melkus1, Simon Hu1, Peder E.Z. Larson1, Sarah J. Nelson1, John Kurhanewicz1, Daniel B. Vigneron1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

A localized correlated spectroscopy sequence using spectral spatial coeherence transfer / water suppression pulses is presented. High bandwidth and low peak power was achieved by phase modulation of the spectral filter and using phase-matched refocusing pulses. Insensitivity to transmitter power offsets is demonstrated in phantoms and compared to correlated spectroscopy acquired using selective presaturation. Preliminary data from vounteers indicate robust water suppression without cross peak degredation due to water contamination.

Keywords

achieved acknowledgments acquisition acquisitions afforded applied authors axes bandwidth biomedical bottom brain calibrated challenging chess choline coherence confound contamination correlated corrupted coupled coupling cross designed detection developed diagonal differ dimension dimensional direct displayed easier encode encodes essentially even extra filter filters flipped flipping fully furthermore galen global glutamate gradient gradients greatly healthy helpful heterogeneous highly human identification imparts impeded in vivo indirect initial insensitive inverse john localized location magnetization magnitude many mark matched measured metabolite metabolites mode modulated modulation must nelson nonlinear offsets orthogonal overlapping padded particularly partners peak peaks phantom playing power profiles project pulse pulses quadrature radiology reasons reduce reed refocused refocusing requirements residual respect robust robustness root saturation scale scaling select selective several simulated since sparsity spatial spatially spectral spectroscopy strength strong strongly subject suppression systems thank tissue tool transfer transfers transform transformed transmitter transverse trey unaffected unchanged upfield useful variation visibility visible volume volunteer water waveform waveforms weakly widths