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Abstract #1977

Effect of Maternal Exposure to High Fat Feeding on Cardiac Metabolism and Function in Offspring

Petronella A. van Ewijk1, 2, Sabina Paglialunga1, Anne Gemmink3, Jos M.G.M. Slenter2, Joachim E. Wildberger2, Jan F. Glatz4, Joris Hoeks1, Matthijs K.C. Hesselink3, Patrick Schrauwen1, Vera B. Schrauwen-Hinderling, 12, Marianne Eline Kooi2

1Human Biology, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 2Radiology, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 3Human Movement Sciences, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands; 4Molecular Genetics, Maastricht University Medical Centre, Maastricht, Limburg, Netherlands

We investigated in mice whether maternal exposure to a high fat (HF) diet increases susceptibility for cardiac lipotoxicity in male offspring on a HF-diet. Cardiac MR-spectroscopy showed initially higher cardiac lipid content in the HF/HF group (at 15 weeks) which decreased in this group with time and tended to be lower at 27 weeks compared to LF/HF. Cardiac CINE-MR imaging showed unchanged ejection fraction. Maximal mitochondrial respiration (determined ex vivo) tended to be lower the HF/HF group at 28 weeks. Maternal HF exposure lead to an initially elevated cardiac lipid content however, on the longer term, differences did not persist.

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Keywords

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