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Abstract #1975

In Vivo 13C MRS Investigation of Alterations in Cerebral Oxidative Metabolism in a Chronic Liver Disease Rat Model

Bernard Lanz1, 2, Cristina Cudalbu2, Valrie A. McLin3, Mario Lepore2, Olivier Braissant4, Rolf Gruetter5, 6

1Department of Radiology, University of Lausanne, Lausanne, Switzerland; 2Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Dpartement de l'Enfant et de l'Adolescent, Unit de Gastroentrologie, Hpatologie et Nutrition, Hpitaux Universitaires de Genve (HUG), Geneva, Switzerland; 4Laboratoire de Chimie Clinique, Dpartement de Pathologie et de Mdecine de Laboratoire, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; 5Laboratory for Functional and Metabolic Imaging (LIFMET), cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 6Departments of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Switzerland

13C MRS combined with the infusion of 13C-labeled glucose is a powerful tool to investigate brain energy metabolism in animal models. In the present study, we analyzed the effect of hepatic encephalopathy induced by chronic liver disease (CLD) on brain oxidative metabolism, using bile duct ligated rats as model for CLD.

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Keywords

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