Meeting Banner
Abstract #1961

Human Studies of Functional MRS at 7T with Semi-LASER

Petr Bednarik1, 2, Ivan Tkac1, Andrea Grant1, Uzay E. Emir1, Dinesh K. Deelchand1, Silvia Mangia1

1CMRR - Dept. of Radiology, University of Minnesota, Minneapolis, MN, United States; 2Molecular and Functional Imaging Laboratory, , CEITEC - Central European Institute of Technology, Masaryk University, , Brno, Czech Republic

In the present work we measured brain metabolite concentrations during a visual stimulation paradigm at 7 T with a full-intensity 1H MRS sequence, semi-LASER. In excellent agreement with our previous findings obtained with STEAM sequence, we observed significant concentration changes within ± 0.2 µmol/g for lactate, glutamate, aspartate and glucose. However, we could not detect changes in glutathione, glycine, glutamine and GABA as reported in other studies, despite higher MRS sensitivity. We conclude that the latter concentration changes are likely to be ascribed to the particular settings of the visual stimulation paradigm.

Abstract PDF

Keywords

achromatic acknowledgments acquisition activated actively analyzed arise ascribed background basis benefit black block blocks bold brain central checkerboard chromatic coil concentration concentrations condition conditions conducting consisted consistently console corrected cortex courses covering critical dark decided dept design despite detection determine eddy emir entire examined expected field fields finally findings flickering fluctuations foundation frequency full functional gain generally glucose glutamate glycine grant half healthy human improve improving indeed indicate inset institute intensity interfaced laboratory labs lactate laser last leveraged like likely localized magnet metabolite metabolites mind molecular namely narrow nine noise notably optimized paired paradigm particular peaks percentage periods presentation previous previously primary prolonged quantified radiology rage reach recently reported representative residual rest revealed selected semi sensitivity settings several shaded shielded side significance simulated special spectra spectrum spin statistical statistically steam stimulation stimuli stimulus strategies strikingly studies subject summed technology transverse ultra uniform units utilized variations visual volume volunteers whether white years