Meeting Banner
Abstract #1958

Can 13C MRS Be Used to Monitor Changes in Hepatic Glycogen Levels Following a Low Dose Oral Glucose Challenge?

S. Bawden1, Mary C. Stephenson1, Elisabetta Ciampi2, J. Lane2, Luca Marciani3, P Morris1, I MacDonald4, Guru P. Aithal4, K. Hunter2, Penelope A. Gowland1

1SPMMRC, University of Nottingham, Nottingham, Notts, United Kingdom; 2Unilever Discover, Bedford, Beds, United Kingdom; 3NDDC Biomedical Research Unit, University of Nottingham, Nottingham, Notts, United Kingdom; 4Medical School, University of Nottingham, Nottingham, Notts, United Kingdom

This study investigates the lower limits of sensitivity in measuring changes in hepatic glycogen levels following an oral glucose challenge using in vivo natural abundance Carbon-13 MR spectroscopy. Subjects were scanned following an overnight fast for baseline values and then hourly for five hours following either a 50g glucose dose or control using a multi-nuclear surface coil. Spectra glycogen peak areas over the timecourse were compared between groups. Changes in gastric content and liver volume we also monitored to consider other related effects. Results show that hepatic glycogen AUCs were significantly higher in the glucose challenge group compared with control.

Abstract PDF

Keywords

abundance acknowledgments adiabatic administered amounts analyze animal assess author aware background basal beds biomedical body breaks broadened calorie carbohydrate challenge cheese coil common concentration consistent consume consumed consumption content continuing control converged decoupled decoupling decrease decreasing delayed depends determine diets distance dose doses downward drawing either emptying energy enhanced entering equivalent error established even expected explains fall fast frequent fully funding gastric glucose glycogen half halted healthy hepatic highlighted hour hourly hours house human hunter individual intake invest investigating kingdom lane linearly liquid little liver males manually meal meals measure measured measuring medical metabolized mixed monitor morris natural occurred oral overall overnight particularly peak phys postprandial power presumably previous production profiles proportion proton published pulse quantity reaches response sample sampling sandwiches scanned school sensitivity significantly since software solution spectra spectral still stomach stored studied studies subject subjects subsequent successfully surface system tend thank trend unit validated volume volunteers water whilst zero