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Abstract #1955

Metabolite Concentration Changes During Motor Activation Using Functional Magnetic Resonance Spectroscopy (FMRS) at 7T

Benot Michel Schaller1, Lijing Xin2, Kieran O'brien3, Rolf Gruetter4

1Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland; 2Department of Radiology, University of Lausanne, Lausanne, Vaud, Switzerland; 3Centre d'Imagerie BioMdicale, University of Geneva, Geneva 14, Geneva, Switzerland; 4Laboratory of Functional and Metabolic Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland

Functional Magnetic Resonance Spectroscopy (fMRS) allows to investigate the small metabolite changes (<0.2mol/g) following a physiological stimulation, by acquiring continuously MR spectra, and provides direct insights into brain metabolism. In this study, a group analysis revealed an increase of [Lac] of 283% and of [Glu] 31% during motor activation.This study establishes that it is possible to investigate the neurochemical profile changes during motor activation. [Lac] and [Glu] increase as has been observed during visual stimulation.

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Keywords

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