Meeting Banner
Abstract #1952

Assessment of Hippocampal Activation and Resting State Glutamate Concentration by Using Functional MRI and 1H MR Spectroscopic Imaging

Alexander Gussew1, Gerd Wagner2, Andreas Deistung3, Reinhard Rzanny1, Patrick Hiepe1, Marianne Cleve1, Karl-Jrgen Br4, Jrgen R. Reichenbach1

1Medical Physics Group, Department of Diagnostic and Interventional Radiology I, Jena University Hospital, Jena, Thuringia, Germany; 2Centre for Neuroimaging, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Thuringia, Germany; 3Medical Physics Group, Department of Diagnostic and Interventional Radiology I, Jena University Hospital - Friedrich Schiller University Jena, Jena, Thuringia, Germany; 4Pain & Autonomics group, Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Thuringia, Germany

The present work describes multimodal fMRI and 1H-CSI measurements of memory task induced functional alternations in hippocampal activity and relationships of these changes to the resting state concentrations of the excitatory neurotransmitter glutamate in a group of healthy volunteers. Significant positive BOLD activations were detected bilaterally in the posterior hippocampus. Task induced activation revealed positive correlation with glutamate concentration, indicating regulation of neuronal activity by the excitatory neurotransmitter turnover.

Abstract PDF

Keywords

absence accounting activated activation activations activity addition allowing allows alterations analyses analyzed anterior application appropriate around ascribed assessment association assumption audience axis background bilateral blue body bold boxes brain chemical choline clockwise coefficients coil combined community composition concentration concentrations condition conditions consisted contrast correlation correlations cortex deactivation dedicated defined diagnostic editing elevated evaluated excitatory experiment explanation finding fixation functional glutamate head healthy hospital impairments improve in vivo included independent indicate individual integrity intensity inter internal investigated investigation late linear magma male mark marker matrix medical memory metabolic metabolites model morphological neuron neuronal neurotransmitter note oriented outside pain paradigm paradigms parallel physics picture pictures positive post posterior predominantly press protocol proton psychiatric psychiatry psychotherapy radiology rage randomly recognize regression regulation related resolution resolved resting rotated scanner several since slice slices spatially spectra spectral spectroscopic spectroscopy status structural studies subjects substantial target tasks thick tissue trio understanding variations volume volunteers whether whole word words yellow