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Abstract #1948

Cholesterol and Its Esters as Serum Biomarkers in Malignant Obstructive Jaundice: A Single Step 1H NMR Metabonomic Approach

Abhinav A. Sonkar1, Shatakshi Srivastava2, Santosh Kumar Singh1, Hari Om Gupta1, Devendra Singh1, Jitendra Kushwaha1, Abhijit Chandra3, Raja Roy2

1SURGERY, KG MEDICAL UNIVERSITY, Lucknow, UTTAR PRADESH, India; 2CBMR, SGPGI, Lucknow, UTTAR PRADESH, India; 3GASTROSURGERY, KG MEDICAL UNIVERSITY, Lucknow, UTTAR PRADESH, India

The paucity of biomarkers for malignant obstructive jaundice results in formidable morbidity and mortality rates. Therefore, alternative diagnostic measures are required for pre-operative management of patients. In the present study, 1H NMR-based metabonomics approach has been applied to investigate small metabolites, cholesterol and bile acid metabolism in benign and malignant causes of obstructive jaundice (OBJ) for identification of serum and bile biomarkers for improved clinical interpretation. A newer, rapid and single step method for serum cholesterol : cholesterol esters estimation has been found to be efficient in differentiating malignancy.

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Keywords

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