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Abstract #1946

Effects of Binge Acute Ethanol Intoxication on Cerebral Neurochemical Profile in Rats: Evidence from in vivo Proton Magnetic Resonance Spectroscopy

Do-Wan Lee1, Jae-Hwa Kim2, Sang-Young Kim1, Dai-Jin Kim2, 3, Jinyoung Jung1, Bo-Young Choe1

1Department of Biomedical Engineering, The Catholic University of Korea, College of Medicine, Seoul, Korea; 2Department of Biomedical Science, The Catholic University of Korea, College of Medicine, Seoul, Korea; 3Department of Psychiatry, Seoul St. Marys Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea

This study aimed to quantitatively assess the cerebral neurochemical effects in hippocampal region in binge ethanol-intoxicated rats by using a 4.7-T 1H-MR Spectroscopy. Our results showed that total choline (tCho; phosphocholine+glycerophosphocholine) concentrations, and tCho/total N-acetylaspartate (tNAA: NAA+N-acetylaspartylglutamate [NAAG]) ratios were significantly lower in binge ethanol group than that in control group. Significantly low tCho concentrations and tCho/tNAA ratios may indicate the cell membrane turnover abnormalities of phosphatidylcholine and changed adaptive mechanism in the hippocampus of binge ethanol intoxicated rats. Thus, we provide quantitative in vivo evidence that binge ethanol exposure causes cerebral neurochemical profile changes in rats, in hippocampal region.

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Keywords

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