Meeting Banner
Abstract #1943

Longitudinal Evaluation of Mild Traumatic Brain Injury: A H-MRS Study

Elijah George1, 2, Steven Roys1, 3, Jiachen Zhuo1, Chandler R. Sours4, Jacqueline Janowich1, Teodora Stoica1, Rao P. Gullapalli1

1Magnetic Resonance Research Center, University of Maryland School of Medicine, Baltimore, MD, United States; 2Bioengineering, University of Maryland, College Park, MD, United States; 3Diagnostic Radiology & Nuclear Medicne, University of Maryland School of Medicine, Baltimore, MD, United States; 4Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, United States

Mild traumatic brain injury (mTBI) patients represent 75% of the viable TBI population. The aim of the current study is to carry out a longitudinal evaluation of mTBI by monitoring metabolic markers of mTBI and their evolution over time such that the findings realized herein will aid improved clinical evaluation of the pathology. We combined neuro-metabolic information with neuropsychological test (NPT) data for the purpose of understanding how current metabolic state affects ongoing cognitive capability, and to determine the efficacy of neuro-metabolic information acquired acutely in predicting outcome of mTBI patients.

Keywords

accurate acute acutely addition affects agrees alterations anatomical arise assessment attention battery biochemical brain carry cell cells cellular cerebral choline chronic chronically clinical cognitive coinciding compromise computer concentration concomitant consistently controls correlation correlations days decrease decreased decreases decreasing deemed deeper desperate determine deviate diagnostic disabilities disrupted documented domains dysfunction edema evaluating evaluation evolution examined excluded experienced findings flow function gives gradual hardly healthy herein history improved include included independent induced inflammation inflammatory injuries injury integrity leads linear literature living longitudinal loss macroscopic major majority marker medicine membrane metabolic metabolite metrics microscopic mild modality molecular monitoring month months necessitates neurological normative occurrence occurring often outcome overall park participants patients physiological plasma plays plot popularly positive post precede predicting previous previously radiology reaction realized reason recovery reduced response samples school score scores seven spectroscopy stage stages stroke strong structural subjects suggested suggesting suggests suppl synthesis table thalamus throughput trauma traumatic trends understanding viable