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Abstract #1940

Volumetric MR Spectroscopic Imaging with Reduced K-Space Acquisitions: Variability and Pathologic Detectability in Mild Traumatic Brain Injuries

Mohammad Sabati1, Jiping Zhan1, Varan Govind1, Kristopher L. Arheart2, Andrew A. Maudsley1

1Radiology, University of Miami, Miami, FL, United States; 2Epidemiology and Public Health, University of Miami, Miami, FL, United States

Several parallel imaging (PI) techniques have been developed for MRSI to reduce data acquisition times. MRSI methods, however, are often sensitivity-limited, and only a few reports have studied the resultant impact that PI may have when applied to MRSI on the outcome of diagnostic accuracy. It therefore remains unknown whether the clinical diagnostic value is maintained for PI-enabled MRSI to detect subtle pathology? This question is addressed by implementing a GRAPPA-MRSI within a fully-automated data processing pipeline and evaluating it using subjects with mild traumatic brain injury who represents a patient group for which the metabolic changes are relatively subtle and diffuse.

Keywords

accuracy acknowledgment acquisition acquisitions additional address altered although analyses assessments atlas automated brain central chess choline clinical coefficients common concentrations content control corrected correlation dataset days demonstrating described details detect determination developed diagnostic enabled encoding epidemiology evaluated evaluating excitation existing final findings fitted fitting five full fully gold good grants health impact implementing improvements included indicated individual induced initial injury institutional inversion linear lipid lists lobar lobe lobes male maps matched materials metabolite metabolites midas middle mild moderate nine normalization noticeably occipital often outcome package parietal pathologic pathologies patient performance pipeline plotted previous processing public quality quantitative radiology receive reconstructed reconstruction reduce reduced registered regression regressions relatively remained remains representative resolution respectively robust sampled scanned scanner score segments sensitivity shorter simulated slice space spatial specificity spectra spectral spectroscopic sped still studied studies subject subjects support table target terms tissue together traumatic trio twenty unit unlike variability volume volumetric water whole yielded