Meeting Banner
Abstract #1918

On SNR Performance of Sequence Designs for Dynamic Imaging of Hyperpolarized 13C Compounds

Kilian Weiss1, Andreas Sigfridsson1, Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

Hyperpolarized metabolically active substances provide a promising approach to investigating in vivo metabolism in real time. However, due to the transient life time of hyperpolarization and fast metabolic conversion of injected substances such as 13C labeled pyruvate, suitable fast dynamic spectroscopic imaging sequences. Several methods have been proposed for efficient spatiotemporal encoding for dynamic imaging of hyperpolarized compounds. The current work presents a theoretical framework based on a compartmental signal model and three frequently used pulse sequence designs for 13C labeled pyruvate are compared in terms of signal-to-noise ratio performance.Spatial and spectral selective excitations are found to be most optimal for signal-to-noise performance. Data acceleration techniques were found to be beneficial for signal-to-nose performance if data acquisitions are limited by technical constraints.

Abstract PDF Poster PDF

Keywords

acceleration according acquisition active adapted allow arrow assumed automatically bandwidth beginning beneficial bicarbonate biomedical bolus cardiac chosen circulation compartment compounds concentration condition considered considering constant constants contrast conversion curves dashed decrease demands depend dependence dependency dependent designs differential discussed duration dynamic dynamics efficient encoded encoding engineering enhanced equations especially every excitation excited fast forward frame framework frequently full fully gradient highest ideal in vivo indicated injected institute investigating kept labeled lead life limit limited limits magnetization metabolic metabolically metabolism model noise nucleus numerical optimal optimally performance planar preferred products promising proposed providing pulse reaction readout readouts real reasons reduced reducing repetition required resolution restricting sampled sampling schematics selective several short shot simulated simulations situation slew solid spatial spectrally spectroscopic spin stay stays steps strength substances suitable system table technical terms theoretical transient written