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Abstract #1913

in vivo Evaluation of 68Ga-Labeled Iron Oxide Nanoparticles as a PET/MR Imaging Probe

Renata Madru1, Thuy Tran2, Adnan Bibic3, Sarah Fredriksson4, Freddy Sthlberg5, Linda Knutsson5, Sven-Erik Strand5

1Medical Radiation Physics, Lunds University, Lund, Sweden; 2Lund University BioImaging Centrum, Lund University, Lund, Skane, Sweden; 3Lund University BioImaging Centrum, Lund University, Lund, Sweden; 4Genovis AB, Lund, Sweden; 5Medical Radiation Physics, Lund University, Lund, Sweden

The purpose of this study was to develop a new PET/MRI probe to improve the current sentinel lymph node technique used for diagnostic and staging of breast cancer and malignant melanoma. Here we demonstrate the feasibility of labeling the synthetized SPIONs with the generator produced Ga-68 and accumulation of the 68Ga-SPIONs in lymph nodes after subcutanious injection in rats, verified by PET and MRI. The results are encouraging for future clinical applications adding important pre-operative information which may lead to new therapeutic strategies.

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Keywords

accepted accumulation acetate added alternative ammonium amount analyzed anatomical anchor animal animals application article axillary blue breast buffer cancer carcinomas cells characterization choice chromatography clearly colloidal colloids combined computer concept containing dark defined deposition develop differentiate differentiation dissecting dorsal drainage dynamic early easily efficiency eluted emission encouraging evaluation examination fast final find fraction future generator gradient guide half highly hind human identification identify importance in vivo inguinal injected injection instant intra iron journal kidneys labeled labeling layer likely limited liver lives lymph lymphatic major malignant mapping matrix measuring medical medicine melanoma metastatic mixed negative node nodes nuclear operatively optimal oxide physics physiological positive positron post primary probe produced quantitative radiation radioactivity rats receiving relies required resolution saline samples sensitive sentinel serum side site slice specificity spleen spread springer stability stable staging step strand studies subcutaneous subcutaneously surgeon system taken therapy thin tomography tracer tracers tumor uptake verified vial visualization