Relaxometric Properties of Gadolinium Chelates of DOTA-Like Ligands with Axially Uneven Distribution of Donor Atoms

Keywords

account acetate acid agent amide analogs arms assessed atom atoms attachment axially backbone bears best biomedical buffer bulky butyl caravan careful central chelate choice comparable complete compounds concentrations conditions confirming contrast control controlled coordinated coordinating counterbalanced coupling decay dependence derivative derivatives design determined difficult direct distribution donor dramatic dynamics either ester exchange exchanging explore explored fast fitting flexible fold gadolinium general hospital impeded increasing inertness influenced kinetic latter library lifetime ligand ligands like limited limits linkage linked little loss luminescence magnitude measured media medical metal methyl model modifications moiety molecular molecule molecules nitrogen novel often opposite optimized panel pendant peter phosphate possibility preparative prepared presence probes products profound properties purified radiology rather reaction remained removal respect respectively rotational school secondary short simple slow slows solutions stability studied surprisingly synthesized synthetically targeting temperature third transversal tuned uneven unit unsubstituted vector water