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Abstract #1894

In Vitro and in Vivo Characterization of (Albumin-Binding) Dendritic MRI Contrast Agents for Dynamic Contrast-Enhanced MRI

Igor Jacobs1, Siem Wouters1, Henk Keizer2, Henk Janssen2, Eliana Gianolio3, Silvio Aime4, Gustav J. Strijkers1, Klaas Nicolay1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands; 2SyMO-Chem BV, Eindhoven, Netherlands; 3Dipartimento di Chimica & Centro di Imaging Molecolare, Universit degli Studi di Torino, Torino, Italy; 4Dipartimento di Chimica & Centro di Imaging Molecolare, Universit degli Studi di Torino, Torino, N\A, Italy

DCE-MRI is widely used for evaluation of tumor treatment. Macromolecular contrast agents may be preferred for determination of specific pharmacokinetic parameters and treatment-induced vascular changes. In this study (albumin-binding) dendritic contrast agents of various molecular weights were extensively characterized. Albumin-binding (confirmed in vitro) led to increased circulation half-lives, while a size-dependent range of circulation half-lives was observed for the non-albumin-binding dendrimers. Tumor/muscle uptake ratios of the dendrimers were higher than of Gd-DOTA. These findings imply that these agents likely possess a range of tumor wash-in and wash-out rates, making them suitable for investigation of the size-dependency of pharmacokinetic parameters.

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Keywords

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