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Abstract #1871

Quantitative 19F MRI and CT Tracking of the Microencapsulated Stem Cells in Peripheral Arterial Disease Model

Guan Wang1, 2, Yingli Fu1, Steven M. Shea3, Judy Cook1, Dara L. Kraitchman1, 4

1Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States; 2Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, United States; 3Center for Applied Medical Imaging, Siemens Corporation, Corporate Research and Technology, Baltimore, MD, United States; 4Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, United States

Microencapsulated stem cell (SC) offers a novel means to transplant mismatched SCs to avoid immunorejection for the treatement of peripheral arterial disease (PAD) that is too extensive for the conventional therapy. We produced dual X-ray/MR-visible microcapsules (XMRCaps) by impregnated the perfluorooctyl bromine (PFOB) to enable cell tracking with non-invasive imaging modalities. Here we first explore quantitative serial cell tracking using c-arm CT and 19F-MRI of XMRCaps in a rabbit PAD model using conventional clinical imaging systems. Results indicate that in vivo XMRCaps volume tracking could be achieved by both CT and MRI, while only MRI demonstrates the XMRCaps degradation.

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Keywords

able accurate agents alginate alterations animals applications array arterial assessment audience averaging avoid background better blue body bromine capsules cardiovascular cell cells channel clinical closely coil comparative computer concentration concentrations concordant consisting constrained cook coronal corporate correlation decreased decreases degradation delivery depth determined disease dose electrical enable engineering enhance environment errors explore field fixed flexible fluorine foundation free geometry gradient grant green highly human identical impregnated impregnating in vivo increasing increment injection injections integrated intensity intramuscular invasive isotropic johns known larger layers lysine markers matrix medical mirroring mismatched modalities model modified molecular noise normalization normalized novel offers partial particular peripheral phantom physician physicist placed precession pulse quantify quantitative rabbit rabbits radiological radiology received reflect repeatability repetition resizing resolution respectively science scientists segmentation segmented serial sets site sites slightly stable steady stem studies suggest supported system systems target technology threshold thresholding tolerance tracked tracking transplant trio validation visibility visible vitro volume volumes week weeks