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Abstract #1840

Enlarged Perivascular Spaces: How Prevalence Might Influence Gene Therapy Trial Design

Miles Olsen1, Barbara Bendlin2, Sterling Johnson2, Jason Huston3, Benjamin Grabow1, Ethan K. Brodsky1, Walter F. Block4

1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States; 2Neuroscience, University of Wisconsin - Madison, Madison, WI, United States; 3Neuroradiology, University of Wisconsin - Madison, Madison, WI, United States; 4Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Enlarged perivascular spaces (EPVS) in the brain are suspected to act as unwanted escape routes for injected drugs during convection enhanced delivery (CED) procedures. We examined 155 subjects in an existing database to determine the prevalence of EPVS in the putamen, a part of the basal ganglia, with the aim to offer guidance on the design of Parkinson's disease gene therapy trials. The subjects in the study (average age 59.8 &[plusmn] 5.97 years) were at about the age of Parkinson's disease onset. The prevalence of atypical EPVS in the putamen (12%) merits consideration.

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