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Abstract #1832

Feasibility of MR Guided HIFU on a 7T Animal MR Scanner, to Evaluate Pathologic Effects of High Intensity Focused Ultrasound in Mice

Martijn Hoogenboom1, Martijn den Brok2, Erik Dumont3, Gosse Adema2, Arend Heerschap1, Jurgen J. Futterer1, 4

1Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 2Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, Gelderland, Netherlands; 3Image Guided Therapy, Pessac, France; 4MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, Overijssel, Netherlands

High intensity focused ultrasound (HIFU) is the only known non-invasive ablation technique available to deliver high energies in a millimeter-sized focus spot. The local effects of HIFU in tissue can be separated into thermal and mechanical effects and depends on different HIFU strategies. These different effects results in various ways of tumor destruction and can be created by different HIFU settings. Therefore, this study has been set up to examine the feasibility of MR guided HIFU in a 7T animal MR system, to investigate different settings and to evaluate the corresponding tumor outcomes.

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Keywords

ablation ablations absorption accuracy accurately acoustic amounts animal applications array arrow arrows audience beam best biomedical blue bore bubbles cavities cavity cells cellular channel clear clinicians collapse combination combined conversion correlate correlates coupling damage days degassed destruction determine disruption distance easily edge energy evaluate feasibility fine focal focus focused forces frequency good guidance guided heat house immunology indicates indication indications induce inevitable injected inside intensity interaction investigate irreversible journal known local localize made maps mechanical mechanisms medical medicine membrane mice millimeter mode necessary necroses necrosis outcomes path pathologic penetrates placed position positioned potential pressure pulsed radiology reached reaches removed resolution respectively response review rise sacrificed scanner secrets section sections sent separated settings shear shots skin software spatial spot stained staining started strategy studies subcutaneously surgery system target technical technology temperature temperatures therapy thermal thermometry third tissue trajectory transducer treatment tumor tuning ultrasound uncertain underneath understanding vascular visualize visualized wave waves wild