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Abstract #1819

Impact of 3D Temperature Probe Localization Variability on MR Thermometry Validation for RF Hyperthermia

Matthew Tarasek1, Lorne Hofstetter1, Ruben Pellicer2, Jurriaan Bakker2, Wouter Numan2, Gyula Kotek2, Eric Fiveland3, Gavin Houston4, Gerard van Rhoon2, Maarten Paulides2, Desmond Yeo1

1MRI, GE Global Research, Niskayuna, NY, United States; 2Erasmus Medical Center, Rotterdam, Netherlands; 3MRI, GE Global Research Center, Niskayuna, NY, United States; 4GE Healthcare, Rotterdam, Netherlands

Validation of MR thermometry (MRT) for RF hyperthermia in a head and neck clinical setup requires accurate co-registration of the inserted temperature probes to MRT data. Here, we explore the use of MR imaging techniques and 3D spline fitting for probe localization. In addition, we investigate how uncertainty in the localization affects the registration of probe and MRT readings. Findings show that a maximum operator-dependent temperature probe placement variability of 2mm along the catheter length accounts for at most a 0.5 degree temperature uncertainty in the MRT maps.

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Keywords

accounts accuracy accurate addition affects anatomy applicator array assume assurance available axial cancer catheter catheters clinical compatible complex constrained constraint coordinate coordinates coronal cubic curve curves cylinder dashed degree depicted discussed distributed distribution done drift effective efficacy enhance error exact explore exterior extracted facilitated final fits fitted fitting frequency functions general global ground head heat heated heating identification in vivo increasing inhomogeneity inserted insertion interior invasive investigate investigation involves justification larger layer length limited localization localized location locations made manually maps matrix measured mimicking minimal modalities much muscle necessitates neck nonlinear noted offset optic optimized outer outside parameterized path phantom phantoms phys pixel placement plot plots plotted position post prevalence probe probes processing proven radio readings reconstruct registration requires resolution safely scanner segmented setup side simulating slice smoothing solid sources space spaced spatial spline strand stray targeted temp temperature text therapy thermo thermometry tissue trajectories treatment treatments truth typically uncertainty validation variability view