Meeting Banner
Abstract #1798

Comparison of Single and Multi-Compartment Models of Diffusion in Fixed Prostate Tissue

Eleftheria Panagiotaki1, Daniel C. Alexander2, Roger Bourne3

1Centre for Medical Image Computing, University College London, London, United Kingdom; 2Centre for Medical Image Computing, Dept Computer Science, University College London, London, United Kingdom; 3 Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia

This study used high-field high-gradient diffusion-weighted (DW) MRI of fixed prostate tissue to explore the key components of an accurate biophysical model for obtaining future biomarkers of cancer and other pathology. We acquired DW-MRI with a rich imaging protocol and selected for modelling two tissue types (from the central and peripheral zone ) to compare four diffusion models.

Keywords

accurate acquisition addition additional although apparent appear approval assumes audience avoid axes best biophysical cancer capture cell cellular central college compartment compartments component components computing confinement consent considering contribute coordinate correlates date decay decrease density departures dependence dept describe development diffusion diffusivity direct discipline distinct distributions either enough epithelial equally errors estimating even evidence example explain explore exponential faculty field fitted fitting fixed free function funded future glandular grade gradient gradients grant gross health highlights improves indicative informed inserted insight invest investigated isotropically just kingdom likely local lumen made marker matrix medical mixture model models mono name naming nodule occur oversimplification peripheral permeability perturbations placed plotting prostate protocol providing pulse pure radiation radical radiology rather recent researchers restricted rich roger saline science sciences selected simple simply spaces specimen sphere squared starting strengths structural studies suggest suggested suggests symbols target tissue trends tube type types underlies urethra versus visible weightings white zone