Meeting Banner
Abstract #1794

Correlative Assessment of BOLD MRI and Gleason Score in Human Prostate Cancer - Preliminary Results

Rami R. Hallac1, Bishoy A. Gayed2, Qing Yuan1, Ramy F. Youssef2, Yao Ding1, Franto Francis3, Claus Roehrborn2, Ganesh Raj2, Robert D. Sims1, Ralph Peter Mason1

1Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Urology, University of Texas Southwestern Medical Center, Dallas, TX, United States; 3Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Oxygen sensitive MRI may provide insights into tumor characteristics. We evaluated the changes in MR contrast and R2* of human prostate cancer in patients accompanying oxygen breathing challenge at 3T MR and correlated observations with resected pathological specimens. BOLD MRI revealed vastly different R2* values between patient tumors, but remarkable similarity to the prostate itself. A strong correlation was found between baseline R2* and Gleason score. We believe these preliminary results warrant further testing as to how R2* and its response to oxygenbreathing challenge correlate with location, pathology, and potentially staging of tumors.

Abstract PDF

Keywords

accompanying addition aggressive antigen approved assessment assisted audience believe biopsy body bold breathed breathing cancer challenge characteristics coil color common confirmed consent contrast correlate correlated correlation correlative ding dynamic element evaluated examined feasible findings gradient heterogeneous histological human hypoxia identified indicating insights intriguingly kinetics location malignant maps mason medical minutes muscle noninvasive observations oncologists oxygen oxygenation part pathological pathologists pathology patient patients peter phenotype phys potentially preliminary preoperative previous progress prostate prostates radiologists radiology remains remarkably representative response revealed robotic routine score sense sensitive southwestern specimen staging strong studies subjects surrounding target though tolerated transmit tumor tumors underwent upon urologists urology vastly warrant weeks workup years yuan