Meeting Banner
Abstract #1787

Metabolomic Fields of Human Prostate Cancer

Emily Decelle1, Johannes Kurth1, 2, W. Scott McDougal1, Chin-Lee Wu1, Leo L. Cheng1

1Massachusetts General Hospital, Boston, MA, United States; 2Charit Universittsmedizin, Berlin, Germany

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Our study of human PCa metabolomics using intact tissue high resolution magic angle spinning MRS showed the potential to improve sensitivity in PCa detection and characterization, including identifying cancer recurrence status. In these studies, we discovered that PCa metabolomic information could delocalize from cancer glands to surrounding histologically benign structures to generate PCa metabolomic fields. The current study is designed to evaluate the ability of metabolomics to reveal PCa clinical and pathological status through the presence of metabolomic fields.

Abstract PDF

Keywords

ability able according added aggressive analyzed annually applications assurance audience benign beyond biochemical cancer cancerous cause characterized chin chronological circles clinic clinical cohort cohorts component contained currently demonstration density detection deviation diagnosed diagnosis diagnostic diamonds differentiate discovered disease divided drastically entire error every examinations existence experimental features field fields fixed form formalin formed frequency general glands heterogeneously histological histology human identify identifying improved indicate individual instance intact intensities intensity lesion limits locking magic majority malignancy malignant measured metabolic metabolite normalized open operating operative overlaps particular particularly pathological pathologist patient patients percentages phenomenon placed plastic populations potential predict principal profiles prognoses prostate prostates protocol quantified recorded rectifying recurrence reduction remaining represent resolution respectively reveal revealed rotor samples sampling score screening sections sensitivity serum sets significance solid spectra spectral spectrometer spectroscopy spinning stage stained statistical status statuses still structures studied studies summed surrounding synchronized target threshold tissue tissues training treatments various volume worldwide