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Abstract #1764

Evaluating MRI T1rho Contrast in Hepatic Cell Carcinoma: Initial Study

Jiayu Sun1, Rui Xia1, Fabao Gao1, Jie Zheng2, Bing Wu1

1Department of Radiology, West China Hospital,Sichuan University, Chengdu, Sichuan, China; 2Mallinckrodt Institute of Radiology,Washington University School of Medicine in St. Louis, St.Louis, MO, United States

6 patients with hepatic cell carcinoma confirmed on liver biopsy were scanned on a Siemens Trio 3.0 T whole body scanner. A novel B0- and B1-insensitive multi-contrast T1rho imaging with segmented trueFISP readout was performed on the slice of the central tumor during end-inspiratory breath holding,Correlation between mean T1 and pathological grading was excellent in all cases for liver tumors.The longer T1rho ratio in tumor tissue may add additional dimension for staging tumors and treatment monitoring.

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Keywords

abdominal able accounts additional altered annually approved axial balanced bing biopsies biopsy body breath cancer carcinoma cell cells central chem china clinical coil committee common complication confirmed contrast correlation coupling deaths dedicated dependent despite detection diagnose dimension discrimination disease ethical evaluate evaluating excellent exchange exchangeable fifth frequencies frequency gold gradient grading hepatic hold holding hospital improved included independent initial insensitive institute intensities intensity inter interactions invasive limited liver local locate locking longer macromolecules malignant mandate materials measure medical medicine million monitoring neoplasms noninvasive novel objective objectively orthogonal pathological pathology patients phys poor potentially prepared prevalence previous previously primary processes progression prospectively protons quantifying radiology rapid readout reflects reliable remains represents reproducibility residual resolution responsible scanned scanner school scout segment segmented series shortcomings significantly slice solutions spatial spin staging static status studies surround tissue tissues tool treatment trio true tumor tumors variability versus water west whole world worldwide