Optimization of Combined Anti-VEGF Plus Radiation Therapy in Brain Tumor Xenograft Models

Keywords

additional addressed administered advancing agent aggressive alone analyzed animal anti approved becoming beginning benefit biophysics blood brain cell cells choice circulation clear cohorts coil college combination combinations combined common concurrently confound consequently contrast control controls corrected create cultured currently daily days decrease degree delivery density dependence depends derived determine determined dose drug drugs efficacy enhanced enhancing entail evaluate evaluating existed fitted fully function furthermore general goal grade growth harvested healthier human hypoxia improve included increasingly induced influence inhibited injected inoculation insight interestingly larger leakage linear little loading maps markers matrix measures measuring median medical minimize model models neurosurgery optimal optimization optimize paradigm paradigms permeability plus post primary processed program proliferation proven providing questions radiation radiology rare rats receive recurrent reported response scanner seven significance since slices south starting studies surface survival systematic tailed temporal therapeutic therapies therapy timing tissue translational transmit treated treatment treatments tumor underway unreliable untreated vascular volume volumes