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Abstract #1698

Investigating Systemic and Tumour-Specific Fluctuations in Tumour R2* Measurement with Independent Component Analysis and Pulse Oximetry

M. R. Gonalves1, Simon Walker-Samuel1, Sean Peter Johnson2, Rosamund Barbara Pedley2, Mark F. Lythgoe1

1UCL Centre for Advanced Biomedical Imaging, Division of Medicine and Institute of Child Health, London, United Kingdom; 2UCL Cancer Institute, London, United Kingdom

Solid tumours have been found to exhibit fluctuating patterns of hypoxia-reoxygenation, which contribute to resistance to chemotherapy and radiotherapy, as well as being associated with a more aggressive phenotype. We present an Independent Component Analysis (ICA)-based approach to identify the contribution of systemic changes in blood oxygenation on tumour fluctuations and separate them from those which are specific to the tumour. We performed a comparison between two colorectal tumour xenograft models with differing vascular characteristics.

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