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Abstract #1696

Mouse Models of Human Cancer: Noninvasive Phenotyping with MRI

Sanaz Jansen1, Yurong Song1, Lilia Ileva2, Lucy Lu1, Terry Van Dyke1

1Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, United States; 2Small Animal Imaging Program, National Cancer Institute, Frederick, MD, United States

We have established a clinically relevant framework for MRI-based characterization of two distinct cancers in mice, brain astrocytoma and breast ductal carcinoma. We applied this approach in over 200 mice representing a diversity of mouse models, from commonly used xenografts to advanced genetically engineered mouse models (GEMMs) wherein key molecular pathways relevant to human astrocytoma (Rb,Ras,PTEN) and breast cancer (Rb,p53, BRCA1) are genetically altered. Our approach represents a new strategy for image-based characterization of cancer in mouse models, including acquisition, analysis and pathologic correlation. With this framework, we can embark on further investigation into the biological underpinnings of image-based features. Temp

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Keywords

accomplish according accurately acquisition adapting address administration advanced affect alterations altered although analogously analyze animal applicability application archive audience biological biology biomedical brain breast cancer cancers carcinoma characterization characterized chelate clinical clinically commonly contrast correlation critical descriptors detect determine developed development diagnostic diagnostics discrepancies disease distinct diversity dynamic earliest easily element embark emerged enhanced enhancing establish establishes even exhibit extraction facilitate features framework genetic genetically genetics goal grade heterogeneity human humans important in vivo included includes injection institute investigation lexicons location majority manipulated margin margins media medium metabolism mice microns models molecular molecularly morphologic motivated mouse national need needed next noninvasive novel obtainable often outcomes pathologic pathways patients permeability phenotype physiologic physiological processes program pulse quantitative rare recapitulated relevant reliably resemble resolution respectively reveal reveals scientists sensitivity several situ solid song specifically stage stages step strategies strategy studies target terry therapeutic therapeutics thick took tumor underlying underpinnings unlike useful validation vast visualize wherein