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Abstract #1691

Improved Accuracy and Precision in Estimation of Intracellular Water Liftime

Jin Zhang1, Melanie Freed2, Joe Rodriguez3, Daniel H. Turnbull3, 4, Sungheon Kim1

1Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, United States; 2Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, United States; 3Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, United States; 4Radiology, New York University School of Medicine, New York, United States

Intracellular water lifetime can be a useful non-invasive biomarker to probe the viability of cell membrane. However, accurate measurement of intracellular water lifetime remains challenging. In this study, we proposed to use multiple flip angles for DCE-MRI data acquisition in order to improve both accuracy and precision of the estimation. The proposed method was investigated using a numerical simulation study as well as a preclinical study with mouse tumor models. Our preliminary results support that the proposed method can substantially reduce the uncertainty in the measurement of intracellular water lifetime.

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Keywords

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