Meeting Banner
Abstract #1648

Haemoglobin-Derived Curve Fitting to Post-Exercise Muscle BOLD Data

Andrew D. Davis1, Michael D. Noseworthy2

1Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada; 2Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada

BOLD imaging of skeletal muscle is difficult to interpret, since the signal depends on muscle perfusion, blood volume, and oxygen saturation. In this study, curves were fit to post-exercise BOLD data by making simple assumptions about [HHb] and [O2Hb] curve shapes and substituting values into published models. Generated curves agreed well with BOLD data, with some variability (0.831 < R-squared < 0.992). The poorer fit of soleus' fast changes compared to gastrocnemius was notable. This simple fit method generated parameters in agreement with prior literature, but further verification is needed to improve confidence before drawing absolute conclusions about physiological parameters.

Abstract PDF Poster PDF

Keywords

accuracy activity advantage afforded agreement although anatomical applied assess assumed assumptions audience axially better biomedical blood bold calf capillary channel coil collected components computer concentration conditions confidence curve curves custom datasets dependent depends derived differing difficult direct distribution draw drawn dynamic electrical elevated engineering evaluate even examining exercise expected exponential fast fits fitting flex functional general generated generating good improve infrared intense interpretation involved known larger literature localization matrix measured medical metabolic minutes model mono much muscle muscles near notably nutritional others overall oxidative oxygen particular perfusion phys physics physiological physiologically plantar plausible poor positive possibly post potential predict previous procedure produced promising protocol published qualitatively quickly radiation rather receive recently regardless remained repetition represent reproduce researchers response returned routine saturation school sciences script sensitive shapes shot simple since skeletal slices sophisticated spectroscopy stable starting subject substituting table target tentative thick triceps type typical unable underlying verification volume written