Meeting Banner
Abstract #1646

Multi-Parametric MRI at 14T for Muscular Dystrophy Mice Treated with Gene Therapy

Donghoon Lee1, Joshua Park1, Jacqueline Wicki2, Jeffrey Chamberlain2, Sue Knoblaugh3, Julie Randolph-Habecker3

1Radiology, University of Washington, Seattle, WA, United States; 2Neurology, University of Washington, Seattle, WA, United States; 3Fred Hutchinson Cancer Research Center, Seattle, WA, United States

Muscular dystrophy is a group of inherited myogenic disorders with no cure. MRI has some key methods that can potentially provide valuable information in developing effective treatment methods for the deadly disease. Unfortunately, only a limited ability of MRI has been utilized to study muscular dystrophy. Here we performed multi-parametric MRI to evaluate treatment responses for mdx (murine model of muscular dystrophy) mice after adeno-associated virus (AAV) vector mediated gene therapy. Our results show T2, apparent diffusion coefficient and magnetization transfer ratio would be potential MR markers to evaluate the treatment efficacy.

Abstract PDF Poster PDF

Keywords

able acquisition acquisitions affected ages although among anisotropy anterior apparent approaches approximately cancer capable carried cellular chamberlain characteristics clinical close coefficient column columns common components conducted containing control corp cure deadly decrease delay dependent determined development diagnostic diffusion dimensional disease disorders dystrophy echoes effective efficacy eleven emerged evaluate evaluation facilitates forms fractional future gene generality generated generating genes gradient hind humans identify important in vivo includes inflammatory inherited limb litter magnetization maps markers mate measured mechanisms mediated medicated mice micro micron monitor mouse muscle muscles muscular neurology neuromuscular noninvasive optimized pane parametric park past patients planar planning potential practice processes protocol quantitative radiology rapid rare recycle reduction refocused resolution respectively responses scout sensitivity shot slice slices spectrometer systemic systemically tensor therapy thick thin timely tissue tool transfer treat treated treatment treatments untreated useful valuable vector virus volume weeks wide