Meeting Banner
Abstract #1624

P-31 Chemical Exchange Saturation Transfer (CEST) Between ATP and Phosphor-Creatine (PCr) at 7T

Jimin Ren1, Baolian Yang2, Ivan E. Dimitrov2, A. Dean Sherry1, 3, Craig R. Malloy1, 4

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Philips Medical System, Cleveland, OH, United States; 3Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States; 4VA North Texas Health Care System, Dallas, TX, United States

Phosphate exchange between PCr and gama-ATP is essential for energy homeostasis in skeletal muscle. The creatine kinase-mediated reaction is conventionally studied by MT technique, often using saturation pulses with high B1 power and long duration. It suffers from the pitfall of large spillover artifact, diminished CEST dynamic range, and increased SAR exposure. We demonstrated it is feasible to use a train of frequency-selective pulses with low saturation power, short saturation time and decreased saturation duty cycle, for generating CEST effect. This was illustrated in the Z-profiles of both PCr and gama-ATP in human skeletal muscle at 7T.

Abstract PDF Poster PDF

Keywords

activity addition advanced advantageous alternative appearance approved artifact bandwidth blue board calf called care characteristics chemical chemistry clearly clinical coil comprised condition consent consequently constants construct control correct covering cycle dean decades decreased dependent described details diminishes direct documented duration duty dynamic easy effectively energy evaluate evaluated even evident exchange experimental exposure extent feasibility felt finally frequency greatly health healthy human illustrated importantly increasing indicative informed institutional interval investigated kinetic larger length literatures magnetization manifested mediated medical minimal minimize mode model muscle needed north observation often opposite parallel partial participants pathology peak peaks performance phosphate phosphor physicists physiologists physiology placed pool power profile protocol pulse pulses quantitative quantitatively reaction read reduced resolution respectively resting retaining revealed saturation selective separated severe shape shaped sharp sherry short side simple skeletal southwestern spectra spectrum spillover step strategy subjects suggesting suppresses surface sweep swept system systems trace traces train transfer typically valuable vary volume widely