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Abstract #1595

In Vivo Cortical Bone MRI with Bound and Pore Water-Discrimination

R. Adam Horch1, 2, Mary Kate Manhard1, 2, Daniel F. Gochberg2, 3, Jeffry S. Nyman4, Mark D. Does1, 2

1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Radiology & Radiological Sciences, Vanderbilt University, Nashville, TN, United States; 4Department of Orthopaedics & Rehabilitation, Vanderbilt University, Nashville, TN, United States

Modern ultrashort echo-time (uTE) MRI is a clinically feasible method for imaging human cortical bone. The conventional uTE signal from cortical bone contains non-discriminated contributions from both bound and pore water. Previous work has linked bound or pore water-discriminated measures to bone mechanical properties, so it is necessary to isolate bound from pore water for diagnostic utility. This work utilizes two modifications to uTE MRI, which incorporate T2-selective adiabatic full passage RF pulses to selectively image bound or pore water. These AFP methods are translated to a clinical scanner and provide quantitative images of bound or pore water in vivo.

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