Elucidating Subcutaneous Depot Formation and Release of the Injectable Anti-Diabetics Taspoglutide in Rats Using in vivo MRI

Keywords

accepted activity address administered administration advanced agent analogue animals anti assessed availability background basil blood body characterization characterize clear clinical coil complex composition conditions consisted constant correlation delivery depot depots designed development device devices diabetes diabetic diabetics discovery dissolution dong dose driving drug elucidating engineered ensuing equipped established examination exposure fairly faster fate field fold form formation formed formulation generally governed head host hours human immediate impart in vivo injectable injected injection injections intensity interventions investigated jellied jellying largely larger latter like liquid local male marked matrix measuring mechanistic minutes model morphology nape novel occurring peptide performance pharmacological pharmacology plasma process prominent properties proportional providing quantitative quantitatively question rare rationale rats receive reduction related release remained resolution respectively route safety sampling scanner shrank significantly site situ slices slow solution strongly structural subcutaneous subsequently successfully suggest supposed suppression surrounded sustained system tended therapeutic tissue treatment type upon uptake vaccine versus view volume volumes yielded