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Abstract #1548

T2 Mapping and Diffusion Weighted Imaging for Quantification of Acute and Chronic Renal Pathology Following Acute Kidney Injury in Mice Comparison with Histopathology

Katja Hueper1, Martin Meier2, Marcel Gutberlet1, Song Rong3, Xia Lu4, Hermann Haller3, Frank Wacker1, Dagmar Hartung1, Faikah Gueler3

1Radiology, Hannover Medical School, Hannover, Germany; 2Institute of Animal Science, Hannover Medical School, Hannover, Germany; 3Nephrology, Hannover Medical School, Hannover, Germany; 4Zunyi Medical College, Wuhan, China

We investigated whether T2mapping and diffusion weighted imaging (DWI) allow monitoring renal pathology after ischemia induced acute kidney injury (AKI) in mice. T2-changes after AKI were most pronounced in the outer medulla. T2-increase was significantly higher after severe than after moderate AKI and correlated with kidney volume loss at d28. ADC was significantly reduced after AKI till d28 and ADC-reduction was more pronounced after severe AKI. Correspondingly, fibrosis and inflammatory cell infiltration were higher after severe than after moderate AKI. Thus, T2mapping and DWI may help to non-invasively determine presence and severity of acute and chronic changes after AKI.

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Keywords

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