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Abstract #1533

Quantification of IVIM Diffusion Parameters of HCC at 3T: Preliminary Experience.

Suguru Kakite1, Hadrien A. Dyvorne1, Karen M. Lee1, Sasan Roayaie2, Ashley Knight-Greenfield1, Ersin Bayram3, Claudia Donnerhack1, Bachir Taouli1

1Department of Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Department of Surgery, Mount Sinai Medical Center, New York, NY, United States; 3GE Healthcare, Milwaukee, WI, United States

IVIM diffusion parameters and ADC values were quantified in 79 HCCs and liver parenchyma in 46 patients at 3T. D (true diffusion coefficient), PF (perfusion fraction) and ADC were all significantly higher in HCC compared to cirrhotic liver parenchyma. There were also significant correlations between D/PF/ADC and tumor necrosis in treated HCCs. There were significant differences in D/ADC and no significant difference in PF between necrotic components and viable components. The ADC value in the necrotic lesion is more affected by the value of D and less affected by the value of PF.

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Keywords

abdominal affected alone apparent approved arrows assess assessed audience background body breathing carcinoma characteristics characterization cirrhosis cirrhotic coefficient coefficients combination component components composite consensus contrast correlation correlations degree diagnosis diffusion disease dynamic enhanced enhancing evaluate evaluated evaluation examples experience exponential fitting fraction free functional greenfield hepatic includes incoherent indicate intensity knight lesions liver lobe male maps measured medical medicine mentioning metrics moderate mono motion mount necrosis necrotic observers organs parametric partially patient patients perfusion physicists planar post preliminary promising pseudo published pure quantification quantify radiologists radiology regional response retrospective school significantly stronger studies subtracted subtraction surgery system systems table target therapy tool treated true tumor tumors underwent untreated viable year