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Abstract #1527

An Automatic Segmentation and Quantitation Technique for Abdominal Fat from MR Images of Obese Rats

Bhanu Prakash KN1, Venkatesh Gopalan1, Swee Shean Lee1, Sendhil S. Velan1

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore

Automatic segmentation and quantification of SAT and VAT from MR images were performed to study the influence of exercise and calorie restriction on obese rats. Distance regularized Level set for delineating the SAT, VAT regions, and fuzzy C-means for classification of fat, organs and non-fat regions was developed and implemented. T2W SE from 35 animals (pre- and post-interventions), L1 L5 of spine were acquired using 7T Bruker Clinscan. Results of segmentation and quantification showed significant decrease of SAT and VAT in exercise and calorie-restriction groups. The proposed method reduced processing time and eliminated inter-and intra- observer variability in quantification of fat.

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Keywords

abdominal active adipose aims allowed among animals anisotropic application automated automatic automation avoids binary biochemical body boundary calorie checked chemical classes cohort coil consistency consortium consuming content contours contract control correlated decrease decreased dependent derived developed diet disease distance distribution divided dual edge edges effective endurance enhancement every evolution exercise expand exploring feasible filter filtered firstly food frequency function fuzzy glucose graph helps hence highest house humans hybrid hypertension important improved induced influence initial insulin intake intensity inter interference intervention interventions intolerance intra laboratory laborious localizing manual mask measured measures merged models molecular needed neighborhood noise obese obesity overall pattern percentage plenum post preserving press process processing program propose protocol rats receive recognition reduce reduced reduces reduction regularized relation resistance resolution respectively restriction saturated segmentation significance slice spatial spectroscopic spectroscopy spine statistically strength studies subcutaneous surface tissue trans transmit transverse twice understand unsaturated useful user variability visceral volume weekdays weeks whereas