Lung Function Assessment in a Mouse Model of Emphysema Using Ultrashort Echo-Time and Oxygen-Enhanced MRI

Keywords

access acknowledgments acquisitions affect alveolar animal animals applied appropriate approved assess assessment axial back blood breathing caused characterized chronic circulation committee compensate compliance components connectivity contribution control damaged days decreased deficits delivered density destruction detect detected disease dissolved drug duration easy elasticity emphysema enhanced enhancement enlargement ethics experiment experimental female fitting fluids frank free function global healthy heterogeneity histological histology impairment implement in vivo indicated induced inflammation inflammatory inhalation instillation intensity intra intranasal inversion investigation investigations knowledge leads local longitudinal loss lung lungs maps marked mass mayer measure measured mechanical mice mild model moderate module molecular mouse muscle observation obstructive oxygen pancreatic patients porcine prior properties protocol proton pulmonary radials recovery reduce reflecting regional require respectively respiratory response revealed saline sectioned segment segmented segments separate series session short shortened shortening slice space spaces statistical steps successfully suited suppression system tailed tissue transfer treated typical understand underway utilize vehicle ventilated ventilation volume walls whole