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Abstract #1480

MRI Equilibrium Signal Mapping Is a Quantitative and Reproducible Alternative to CT for the Estimation of Lung Density in COPD

Weijuan Zhang1, 2, Penny L. Hubbard1, 2, Eva Bondesson3, Lars Wigstrm4, Simon S. Young5, David Singh6, Josephine H. Naish1, 2, Geoffrey J. M. Parker1, 2

1Centre of Imaging Sciences, The University of Manchester, Manchester, United Kingdom; 2Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom; 3Camurus AB, Lund, Sweden; 4Respiratory &Inflammation Therapy, Clinical development, AstraZeneca, Mlndal, Sweden; 5Personalised Healthcare and Biomarkers, AstraZeneca, Alderley Park, United Kingdom; 6Medicines Evaluation Unit, University Hospital of South Manchester Foundation Trust, Manchester, United Kingdom

This study demonstrated a good correlation between MRI equilibrium signal maps and CT measurements in the estimation of lung density in COPD.

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Keywords

alternative biomedical clinical density development equilibrium estimation evaluation foundation hospital inflammation institute kingdom lung mapping medicines park parker penny quantitative reproducible respiratory sciences south therapy trust unit young