Meeting Banner
Abstract #1475

Hyperpolarized 83Kr Imaging on a Clinical 3 T System

Daniel James Lee1, Joseph Six2, Matthew Clemence3, Paul M. Glover1, Thomas Meersmann2, Karl Stupic2, 4

1SPMMRC, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2Medical School, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 3Philips Healthcare, Guildford, Surrey, United Kingdom; 4National Institute of Standards and Technology, Boulder, CO, United States

Imaging of hyperpolarized 83Kr has been achieved on a clinically available 3T system. The isotope 83Kr has the potential to become a new contrast agent for respiratory MRI where changes such as inflammation, lung surfactant concentration, and alveolar shape could be monitored as important pathologies for lung disease. The presence of 83Kr was confirmed spectroscopically and images of a phantom are presented.

Keywords

accounts acknowledgments advances affected allows alveolar applications approximately array assessed atmosphere audience axial become best biomedical boulder bridging built carry cause cell class clearly clinical clinically closed coil contained contrast currently density described design destruction detecting detection diagnosis diagram diameter diode disease distribution dynamic environment evaluate exposure feasibility field flow fluid frequency funded future gaps glover helium humans ideal improved in vivo included inflammation initial instruments intensity introduced invasive isotope isotopes kingdom krypton larger laser lasers length limits long longer lung lungs made mapping measured mixture modality monitored much need nitrogen noble novel nuclear oxygen pathologies person phantom phys physics plot polarization port ports potential pressure prior probed produced promise pulmonary pulse pumping reading receive reducing repetition requires resolution resonant respiratory review rising rodent saddle school science sciences sensitivity seven shape shortened side significantly spectroscopy spectrum spin stopped storage suitable surrey system target technology term tissue transition transmit treatment versus vital volume yields