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Abstract #1453

Assessment of Pulmonary Capillary Blood Pulsation in Severe COPD Using Hyperpolarized 129Xe CSSR

Kai Ruppert1, Talissa A. Altes1, Jaime F. Mata1, Iulian C. Ruset2, 3, F. William Hersman2, 3, John P. Mugler, III1

1University of Virginia, Charlottesville, VA, United States; 2Xemed, LLC, Durham, NH, United States; 3University of New Hampshire, Durham, NH, United States

A recent, autopsy-based study found surprisingly that most deaths in subjects with severe chronic obstructive pulmonary disease (COPD) may actually be due to cardiovascular causes. The purpose of our studies was an initial assessment of pulsatile blood flow in subjects with severe COPD as detected by Chemical Shift Saturation Recovery MR spectroscopy. We found that, compared to an age-matched second-hand smoker, the blood flow pulsations in the COPD patients was either absent or much less coherent. We hypothesize, that emphysematous lung tissue destruction, or regional pulmonary hypertension, in subjects with severe COPD reduces the coherence of the various regional pulsations.

Keywords

abnormal abnormalities absent actually amplitude applied assessment audience autopsy blood blue breath butler cancellation capacity capillaries capillary cardiovascular cell characterize chemical chest chronic clinical clinically coherence coil commonly consent corrected cosine currently deaths decay defects delay described destroy destruction detected disappearance discernible disease dissolved drawn emphysematous enriched excitation exponential exposure feasible fitted fixed flow fluctuations form frequency function global gold gradient grant hand healthy heavy held history hold holding hypertension illness included induced induction inhalation inhaled initial integrals integrated investigated john lack lead least lung magnetization matched might nature need oscillations partially particularly peak peaks periodic periodicity phys physician physicians plasma polarized possibly predicted prototype pulmonary pulsation pulsations pulse pulses ranging recent recovery reflect regional residing residual rhythmic saturation separate sets severe since smoke smoking solutions sought spectra spectral spectroscopy squared stage starting studies subjects submitted sufficiently supervised surprisingly system target temporal throughout tissue variable various ventilation visible volume xenon years