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Abstract #1432

Analysis of Right Ventricular Kinetic Energy in an Acute PAH Animal Model Using 4D Flow MRI.

Alejandro Roldn-Alzate1, Philip C. Kilgas2, Kevin M. Johnson2, Oliver Wieben1, 2, Christopher J. Francois3

1Radiology, University of Wisconsin, Madison, WI, United States; 2Medical Physics, University of Wisconsin, Madison, WI, United States; 3Radiology, University of Wisconsin-Madison, Madison, WI, United States

In patients with pulmonary hypertension (PH), blood pressure and resistance in the pulmonary circulation are elevated, leading to decreases in right ventricle (RV) function. The correlation between ventricular-vascular coupling efficiency and non-invasive metrics of PA and RV function in PH is unclear. Results in this pilot study demonstrate the feasibility of 4D flow MRI for quantifying RV kinetic energy in an animal model of acute thromboembolic PH. Future studies will concentrate on the implementation of the technique for the analysis of human PH patients.

Keywords

acquisition acquisitions acute administration adult affect anesthesia animal animals approval arbor arterial assess audience beads beagles blood blue calculation calculations canine cardiac cardiopulmonary cine clinical complex conditions contrast correlation coupling dataset decrease decreased density development diagnostics diastole dimensional directional discovery disease distribution dynamic dynamics earlier efficiency ejection encoding energy expected extent failure feasibility female findings flow fraction frames function future gating give healthy heart hold human humans hypertension important indicating induced induction injection insight interestingly intravenous invasive isotropic kinetic larger lead linear lungs magnitude maintained mass measured medical methodology metrics micro mimics model paired peak peaks physics physiology pilot post power prior prognostic progressive projection pulmonary pumping qualitatively quantified quantifying radially radiology reconstruction reduction regression remodeling required resistance resolution resolved respect respectively schematic segmented spatial specifically squared statistically studied studies subjects suggests summarizes summary supported system systole systolic table target understanding units unmanaged upstream vascular vastly velocity ventricle ventricular volume volumes