Meeting Banner
Abstract #1409

Effect of Contrast Dose, Post-Contrast Acquisition Time, Myocardial Regionality, Cardiac Cycle and Gender on Dynamic-Equilibrium Contrast CMR Measurement of Myocardial Extracellular Volume

Christopher A. Miller1, 2, Josephine H. Naish1, Glyn Coutts3, David Clark4, Sha Zhou1, Geoffrey J. M. Parker1, Matthias Schmitt, 12

1Centre for Imaging Sciences & Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom; 2North West Heart Centre and The Transplant Centre, University Hospital of South Manchester, Manchester, United Kingdom; 3Christie Medical Physics and Engineering, The Christie Hospital, Manchester, United Kingdom; 4Alliance Medical Cardiac MRI Unit, Manchester, United Kingdom

This study provides whole-heart, histological validation of; 1. Dynamic-equilibrium cardiovascular magnetic resonance (DynEq-CMR), where myocardial extracellular volume (ECV) is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.

Abstract PDF

Keywords

according accuracy achieved acquisition adjusted administration aimed alliance applied assess assuming asymptomatic audience axis biomedical blood bolus cardiac cardiologists cardiovascular characteristics commonly compartment confirmed contrast correction cycle derived determined deviation diastole diastolic differ dose dynamic early engineering equilibrium evaluate examination extracellular female females function gadolinium gender global healthy heart height highest hospital incomplete increasingly indexed institute intervals inversion kinetic kingdom lateral linearly locker look lowest male maps mass matched measured medical miller model modified myocardial myocardium negligible north overall parker patient phantom physicists physics plotted post prior prospectively quantified radiologists received recovery regional repeated researchers risk scanning sciences septum short shortened significantly south split studies subjects suggests systole systolic table target transplant unit varied varies ventricular volume volunteers wall wave west