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Abstract #1392

Comparison of Left Ventricle Circumferential Strain in Animals Subjected to Coronary Artery Microemboli or Occlusion/Reperfusion

Mohammed Suhail1, 2, Mark W. Wilson1, Steven W. Hetts1, Robert F. Mattrey3, Maythem Saeed1

1Department of Radiology, University of California San Francisco, San Francisco, CA, United States; 2School of Medicine, University of California San Diego, La Jolla, CA, United States; 3Department of Radiology, University of California San Diego, La Jolla, CA, United States

This MRI study was designed to compare phasic, peak strain and time to peak strain after acute myocardial infarction caused by LAD coronary microembolization and occlusion/reperfusion. The infarct size on delayed contrast enhanced MRI was significantly smaller in animals subjected to microembolization compared to LAD occlusion/reperfusion. Microemboli and LAD occlusion significantly decreased peak strain when compared to remote myocardium. However, the difference in peak strain between interventions was not significant. The pattern of myocardial infarct plays a role in ventricular synchronization. Furthermore, there is disproportion between infarction size and circumferential strain in animals subjected to microembolization and LAD occlusion/reperfusion.

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Keywords

acute affect analyzed animals appropriate artery axis branch cardiac catheter catheterized caused chamber circumferential committee commonly compensatory contrast control controls coronary correlation curves days decrease decreased deformation delayed delivered delivery designed diagonal diameter differential disproportion disproportional distal dysfunction either ejection enable enhanced evidence field fraction function furthermore global gradient guidelines harp heart hearts hypothesis important independent index indicating infarct infarction intervention interventions introduced inversion limitations longitudinal major mark mass measure mechanical medical medicine motion myocardial myocardium nonparametric novel occlusion outcome paired pattern peak placed planar plays predictor quantification quantitative radiology reach recognized recommendations recommended recovery reflecting regional regulating remote report respectively revealed risk role scanner school score served short significantly smaller society speckle strain stratification subjected suggesting swine synchronization systems systolic tagged territory tracking turbo unpaired ventricle ventricles ventricular volume wall writing