Meeting Banner
Abstract #1379

Effects of Perfusion on Cardiac MR Diffusion Measurements

Osama Abdullah1, Arnold David Gomez2, Samer Merchant2, Owen Stedham2, Michael Heidinger3, Steven Poelzing3, Edward Hsu2

1Bioengineering , University of Utah, salt lake city, UT, United States; 2Bioengineering, University of Utah, salt lake city, UT, United States; 3Cardiovascular Research and Training Institute, University of Utah, salt lake, UT, United States

MR diffusion measurements were investigated in an animal model of isolated perfused heart and analyzed as functions of myocardial perfusion, diffusion encoding b-value and myofiber orientation. Results indicate that perfusion accounts for 14% and 10% of the apparent diffusion coefficients observed at normal flow in directions parallel and perpendicular to the myofibers, respectively. The contributions of perfusion increase when only lower b-values and decrease when only higher b-values were used to measure diffusion. These findings have practical implications for the design and interpretation of in vivo cardiac diffusion and DTI experiments

Abstract PDF Poster PDF

Keywords

accentuated according acknowledgments albeit alleviate allowed animal apparent arrested artifacts ascertain assess asterisks axis beat become bioengineering black boxes bulk cardiac cardiovascular caution choice circumferential city column compatible concern conditions consistent constraint contain control denoting depend dependence dependency dependent depending described despite diffusion diffusivity direct eigenvalues either empirically encoded encoding entries examine excised feasible fibers findings flow full general guinea hardware heart hearts implications in vivo incoherent indicate inside insignificant instrument interpreting inversion isolated known lake largely leads liver locations loop maps memory merchant methodology model moderate mostly motion muscle myocardial namely normalized observations often organs parallel particular percent perfused perfusion perpendicular phantom physiology placed potassium precise precisely pressure previously pronounced quantified radiology ranging read readout recovery regional remain reported representative resolution resonator respectively salt scalar scanned sealed sensitivity settings short shot slice solution structure studies suggest system table taking tensor tissue trace training tube turn unknown ventricular verified viability warranted water yield