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Abstract #1360

In Vivo Ultra Short TE (UTE) MRI Detects Diffuse Fibrosis in Hypertrophic Mouse Hearts

Bastiaan J. van Nierop1, Jules L. Nelissen1, Noortje A.M. Bax2, Abdallah G. Motaal1, Larry de Graaf1, Klaas Nicolay1, Gustav J. Strijkers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord Brabant, Netherlands; 2Soft Tissue Biomechanics and Engineering, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Noord Brabant, Netherlands

Fibrosis is an important hallmark of various cardiac pathologies. Noninvasive imaging techniques for the assessment of fibrosis are highly desired. Here, we report on in vivo 3D ultra short TE (UTE) MRI for the assessment of diffuse myocardial fibrosis in mouse pressure overload-induced hypertrophy. The in vivo signal change from short-TE to long-TE images was larger in hypertrophic as compared to control hearts. Ex vivo measurements revealed that this can be attributed to T2* changes as a consequence of the presence of diffuse fibrosis. Thus, UTE MRI could provide a noninvasive readout for diffuse fibrosis in relation to myocardial hypertrophy.

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Keywords

accumulation acquisition agents amount artifacts assessment audience axis behavior biomedical block blood cardiovascular cell chelate chemical clinical collagen component components consisting constant constriction contrast control decaying decrease depended described detail detect determined diagnosis diffuse done engineering especially essentially every examples excessive excised exponential extracellular failure fast fibrosis finally fitted foundation fractional function gadolinium gated hallmark healthy heart hearts highly histology hypertrophy hypothesis immediately improve improved in vivo induced kinetics larger least limit limited linear linearly lipid long matrix measure measured mechanisms medicine mice model molecular mouse myocardial myocardium noninvasive novel opportunity orientation oscillating overload paraffin particularly pathologies patients pivotal plays pool pools positioned presence pressure prevent previously proteins protons prove pulse quantified radial readout regional related relation replacement representative respiratory restrictions revealed risk role saturation sections selective severe short slice slices slightly slow soft stained stratification studied supported target technology tissue towards transition translation translational transverse triggered ultra various visualize visually wave weeks