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Abstract #1333

A Non-Invasive Assessment of Cardiopulmonary Hemodynamics with MRI

Octavia Bane1, 2, Sanjiv J. Shah3, Michael J. Cuttica4, Jeremy D. Collins1, Senthil Selvaraj5, Christoph Guetter6, James C. Carr1, Timothy J. Carroll1, 2

1Feinberg School of Medicine, Radiology, Northwestern University, Chicago, IL, United States; 2Biomedical Engineering, Northwestern University, Evanston, IL, United States; 3Feinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL, United States; 4Feinberg School of Medicine, Pulmonary Care, Northwestern University, Chicago, IL, United States; 5Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; 6Corporate Research, Siemens Corporation, Princeton, NJ, United States

Pulmonary hypertension (PH) is a disease of the pulmonary vasculature, with subtypes pulmonary arterial and pulmonary venous hypertension, usually diagnosed by right-heart catheterization (RHC). We propose a method to measure several cardiopulmonary parameters of interest in PH, non-invasively by MRI. The parameters are subsequently used to calculate pulmonary artery pressure waveforms according to the two element windkessel model . We validated our approach in a study of 8 consecutive patients with suspected PH (mean pulmonary arterial pressure, mPAP>25 mmHg), who underwent RHC, Doppler echocardiography and cardiac MRI. We found no statistically significant difference between RHC and MRI.

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Keywords

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