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Abstract #1331

Cerebral Blood Flow in Pediatric Multiple-Sclerosis Patients and Age-Matched Controls Using Phase-Contrast MRI

Christopher K. Macgowan1, Katherine Chan, Suzanne Laughlin2, Stephanie Khan3, Ruth Ann Marrie4, Brenda Banwell3

1Medical Biophysics, University of Toronto / Hospital for Sick Children, Toronto, ON, Canada; 2Medical Imaging, University of Toronto / Hospital for Sick Children, Toronto, ON, Canada; 3Pediatrics (Neurology), University of Toronto / Hospital for Sick Children, Toronto, ON, Canada; 4Internal Medicine (Neurology) and Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada

Using phase-contrast MRI, we have quantified cerebral blood flow in pediatric subjects with multiple sclerosis (N=26) versus age-matched controls (N=26). This study establishes reference values for normal pediatric flow for future neurological studies. Arterial and venous flow measurements were highly reproducible within individuals. However, inter-subject variability in venous flows underscores the difficulty of attributing pathological significance to individual venous flows.

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Keywords

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