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Abstract #1257

Aging Deficits in Axonal Transport Are Exacerbated by Abeta Plaques: An MEMRI Study

Elaine L. Bearer1, 2, Joseph J. Gallagher2, Aaron Gonzales3, XiaoWei Zhang2, Russell E. Jacobs4

1Pathology, University of New Mexico, Health Sciences Center, Albuquerque, NM, United States; 2Biology, California Institute of Technology, Pasadena, CA, United States; 3Pathology, University of New Mexico, Health Sciences Center, Abuquerque, NM, United States; 4Beckman Institute, California Institute of Technology, Pasadena, CA, United States

Transport defects impact neuronal survival. We are developing and applying high-field MEMRI to detect and measure transport dynamics in living mouse models of neurodegenerative diseases. Here we present results from the aged double transgenic mice expressing human mutant amyoid precursor protein under control of the Tet-off promotor. Statistical parametric mapping and ROI analyses demonstrate decreased Mn2+ accumulation in the contralateral hippocampus and the medial septal nuclei in the forebrain after injection in the right hippocampus in aged versus young mice which is exacerbated with in the APP over-expressors who also display numerous Abeta plaques.

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Keywords

active aged aging align animal animals appears arrows atlas axon axons barely bearer begun biology blue body brain carries cell cellular circuit coil completed components consistent contra contributing control coordinates critical currently dataset datasets decline declines defects deficits delivers dimension discovery disease distal double either elaboration enhanced exacerbated explaining expressed expressing expression familial fixed form full function gelatin genotype genotypes gives gray halo health highly hypothesis hypothesized identified immediately injected injection injections institute intense intensity involved lacking larger linear little location machinery maintenance manganese mapping maps materials matrix medial memory mice microns microscopy minimal minute models mouse mutant mutants nerve neuronal normally note nucleus occupy onto paired parallel parametric pathology perfusion plaques post precursor preferentially projected projection protein rare reached reconstruction report resolution robust sacrificed sciences sections significance silver since stain stained statistical stripping studies synapses system technology terminals throughout together transmits transport vesicular visual volume warped whereas yellow yielding young