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Abstract #1250

Test-Retest Reproducibility of T1rho Mapping in Brain at 3T

Trevor Andrews1, 2, Scott Hipko2, Jay Gonyea2, Richard Watts2

1Philips Healthcare, Cleveland, OH, United States; 2Department of Radiology, University of Vermont College of Medicine, Burlington, VT, United States

This study evaluates the test-retest reproducibility of a novel T1rho mapping acquisition in brain. The purpose is to assess the utility of this method for future clinical trials utilizing T1rho mapping in patients (e.g. with Alzheimer's Disease, Parkinson's Disease).

Keywords

accuracy acquisition actual adulthood allow anatomical applied approved artifacts assess atlas attenuated bias brain brains calculations cerebral channel clear coil college controls cortical coverage covering defined degree dementia dependence detection deviation deviations diagnosed differentiation dilated disease duration durations earlier elderly enough entire especially evaluates even every exponential fact feasible fluid free frequency generally gray head healthy histogram history human identical important in vivo included individual inherent intersection least limited linear lobe lock major many mapping maps masks matrix measure measures medial medicine months neurological noise normalized normative novel oxford partly pathologic pathological patient patients person population populations possibly potential previous processing produced quality quantitative radiology random recent recently recruited reflecting repeated reported reproducibility resolution respectively retest robust scanner segmentation segmented session since slice space spatial spatially spin squares studies subject subjects submitted suffer suffered suggests supported suppressed table technically temporal throughout tracts turbo typically unfortunately unified utility variable variations volunteers watts white whole