Meeting Banner
Abstract #1246

Tract Specific Analysis Reveals the Impact of Childhood Manganese Exposure on the Corpus Callosum

Yi Lao*1, 2, Laurie Anne Dion3, Fernando Yepes, 24, Guillaume Gilbert5, 6, Maryse Bouchard5, Dave Saint Amour^3, Natasha Lepore1, 2

1University of Southern California, Los Angeles, CA, United States; 2Children's Hospital Los Angeles, Los Angeles, CA, United States; 3Universit du Qubec Montral, Montreal, QC, Canada; 4University of Barcelona, Barcelona, Catalua, Spain; 5Universit de Montral, Montral, QC, Canada; 6Philips Healthcare, Montreal, QC, Canada

Long-term Manganese exposure(Mn) will cause neuromotor and deficits. However, studies focusing on the adverse effects of Mn on white matter microstructures are few in number. Moreover, white matter structures may not be accurately mapped in traditional voxel-based analysis which is widely used in related studies.

Keywords

accuracy accurately adaption additionally adult affected alterations amour anisotropy author automated axial begins better brain broad cause childhood children chronic chronically cognitive column columns computational connections consistent contribution controls corpus correction damage decreased deficits delineated density diameter differ diffusion diffusivity discrepancy displays drinking employed equal explanation exposed exposure fibers findings fractional frontal fully gender gilbert greater hospital houses humans impact injury issue known last lead localization long look manganese manually mapped matched measures medical middle negligible particular parts permutations planar potential preprocessed quantify radial rats recent registered registration registrations respectively response reveals rodent saint scanner semi sign significantly southern special statistical structures studies subjects subsequently suggest template tensor tensors term tract tracts traditional transactions typical vulnerable water welders white whole wielders years zoom